Genetic covariance between central corneal thickness and anterior chamber volume: a Hungarian twin study
Title | Genetic covariance between central corneal thickness and anterior chamber volume: a Hungarian twin study |
Publication Type | Journal Article |
Authors | Toth, GZ, A. Racz, A. D. Tarnoki, D. L. Tarnoki, Z. Szekelyhidi, L. Littvay, ZZ Nagy, I. Suveges, and J. Nemeth |
Journal title | Twin Research and Human Genetics |
Year | 2014 |
Volume | 17 |
Issue | 5 |
Abstract | Background: Few, and inconsistent, studies have showed high heritability of some parameters of the anterior segment of the eye; however, no heritability of anterior chamber volume (ACV) has been reported, and no study has been performed to investigate the correlation between the ACV and central corneal thickness (CCT). Methods: Anterior segment measurements (Pentacam, Oculus) were obtained from 220 eyes of 110 adult Hungarian twins (41 monozygotic and 14 same-sex dizygotic pairs; 80% women; age 48.6 ± 15.5 years) obtained from the Hungarian Twin Registry. Results: Age- and sex-adjusted heritability of ACV was 85% (bootstrapped 95% confidence interval; CI: 69% to 93%), and 88% for CCT (CI: 79% to 95%). Common environmental effects had no influence, and unshared environmental factors were responsible for 12% and 15% of the variance, respectively. The correlation between ACV and CCT was negative and significant (rph = −0.35, p < .05), and genetic factors accounted for the covariance significantly (0.934; CI: 0.418, 1.061) based on the bivariate Cholesky decomposition model. Conclusion: These findings support the high heritability of ACV and central corneal thickness, and a strong genetic covariance between them, which underscores the importance of identification of the specific genetic factors and the family risk-based screening of disorders related to these variables, such as open-angle and also angle closure glaucoma and corneal endothelial alterations. |
DOI | https://doi.org/10.1017/thg.2014.54 |
Publisher link | https://www.cambridge.org/core/journals/twin-research-and-human-genetics/article/genetic-covariance-between-central-corneal-thickness-and-anterior-chamber-volume-a-hungarian-twin-study/DAD2AD9F649F9C5DFED70AF82538A79F |