Heritability of the femoral intima media thickness

TitleHeritability of the femoral intima media thickness
Publication TypeJournal Article
AuthorsFejer, B., A. D. Tarnoki, D. L. Tarnoki, P. Lucatelli, L. Littvay, P. Maurovich-Horvat, AL Jermendy, A. Kovacs, E. Godor, C. Fagnani, M. A. Stazi, A. A. Molnar, F. Fanelli, C. Cirelli, F. Farina, C. Baracchini, G. Meneghetti, G. Pucci, G. Jermendy, B. Merkely, G. Schillaci, and E. Medda
Journal titleEuropean Journal of Internal Medicine
Year2017
Pages44-48
Volume41
Abstract

Background
The measurement of femoral intima-media thickness (IMT) is underutilized in the clinical practice, although it is a surrogate marker of cardiovascular disease.

Materials and methods
388 Hungarian and Italian twins (121 monozygotic, 73 dizygotic pairs) underwent bilateral B-mode sonography of femoral arteries. IMT was measured by semiautomated software, where available, or by calipers.

Results
Within-pair correlation in monozygotic twins was higher than in dizygotics for each parameter. Age-, sex- and country-adjusted genetic effect accounted for 43.9% (95% confidence interval, CI 21.3%–65.2%) and 47.2% (95% CI, 31.4%–62.6%) of the variance of common and superficial femoral artery IMT, respectively, and unshared environmental effect for 56.1% (95% CI 34.6%–78.5%) and 52.8% (95% CI, 37.2%–68.5%). These results did not change significantly after correcting for body mass index or central systolic blood pressure.

Conclusions
Genetic factors have a moderate role in the determination of common and superficial femoral IMT; however, the influence of environmental (lifestyle) factors remains still relevant. Environmental factors may have a role in influencing the genetic predisposition for femoral vascular hypertrophy.

DOIhttps://doi.org/10.1016/j.ejim.2017.02.019
Publisher linkhttps://www.sciencedirect.com/science/article/pii/S095362051730081X?via%3Dihub
Unit: 
Department of Political Science
Doctoral School of Political Science, Public Policy and International Relations